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Entner Doudoroff pathway

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
D-glucose + NADP+ <=> D-glucono-1,5-lactone + NADPH + H+ 1.1.1.119 glucose 1-dehydrogenase (NADP+)
1.1.1.179 D-xylose 1-dehydrogenase (NADP+, D-xylono-1,5-lactone-forming)
1.1.1.359 aldose 1-dehydrogenase [NAD(P)+]
1.1.1.360 glucose/galactose 1-dehydrogenase
1.1.1.424 D-xylose 1-dehydrogenase (NADP+, D-xylono-1,4-lactone-forming)
1.1.1.47 glucose 1-dehydrogenase [NAD(P)+]
1.3.1.20 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase







6-phosphogluconate <=> 2-keto-3-deoxy_phosphogluconate + H2O 4.2.1.12 phosphogluconate dehydratase

2-dehydro-3-deoxy-D-gluconate <=> D-glyceraldehyde + pyruvate 4.1.2.14 2-dehydro-3-deoxy-phosphogluconate aldolase
4.1.2.20 2-dehydro-3-deoxyglucarate aldolase
4.1.2.51 2-dehydro-3-deoxy-D-gluconate aldolase
4.1.2.55 2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deoxy-6-phosphogalactonate aldolase




D-glyceraldehyde_3-phosphate + NAD+ + H2O <=> 3-phospho-D-glycerate + NADH + H+ 1.2.1.12 glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)
1.2.1.3 aldehyde dehydrogenase (NAD+)
1.2.1.5 aldehyde dehydrogenase [NAD(P)+]
1.2.1.88 L-glutamate gamma-semialdehyde dehydrogenase
1.2.1.9 glyceraldehyde-3-phosphate dehydrogenase (NADP+)
1.2.1.90 glyceraldehyde-3-phosphate dehydrogenase [NAD(P)+]






2-dehydro-3-deoxy-D-gluconate <=> D-glyceraldehyde + pyruvate 4.1.2.14 2-dehydro-3-deoxy-phosphogluconate aldolase
4.1.2.20 2-dehydro-3-deoxyglucarate aldolase
4.1.2.51 2-dehydro-3-deoxy-D-gluconate aldolase
4.1.2.55 2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deoxy-6-phosphogalactonate aldolase




2-phospho-D-glycerate <=> 3-phospho-D-glycerate 5.4.2.11 phosphoglycerate mutase (2,3-diphosphoglycerate-dependent)
5.4.2.12 phosphoglycerate mutase (2,3-diphosphoglycerate-independent)


D-glucose + NAD+ <=> D-glucono-1,5-lactone + NADH + H+ 1.1.1.118 glucose 1-dehydrogenase (NAD+)
1.1.1.119 glucose 1-dehydrogenase (NADP+)
1.1.1.121 aldose 1-dehydrogenase (NAD+)
1.1.1.179 D-xylose 1-dehydrogenase (NADP+, D-xylono-1,5-lactone-forming)
1.1.1.47 glucose 1-dehydrogenase [NAD(P)+]





D-gluconate <=> H2O + 2-dehydro-3-deoxy-D-gluconate 4.2.1.140 gluconate/galactonate dehydratase
4.2.1.39 gluconate dehydratase
4.2.1.82 xylonate dehydratase
4.2.1.9 dihydroxy-acid dehydratase




2-keto-3-deoxy_phosphogluconate <=> D-glyceraldehyde_3-phosphate + pyruvate 4.1.2.14 2-dehydro-3-deoxy-phosphogluconate aldolase
4.1.2.20 2-dehydro-3-deoxyglucarate aldolase
4.1.2.51 2-dehydro-3-deoxy-D-gluconate aldolase
4.1.2.55 2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deoxy-6-phosphogalactonate aldolase




2-dehydro-3-deoxy-D-gluconate + ATP <=> H+ + 2-keto-3-deoxy_phosphogluconate + ADP 2.7.1.178 2-dehydro-3-deoxyglucono/galactono-kinase
2.7.1.45 2-dehydro-3-deoxygluconokinase


D-glyceraldehyde + H2O + NADP+ <=> D-glycerate + NADPH + H+ 1.2.1.19 aminobutyraldehyde dehydrogenase
1.2.1.26 2,5-dioxovalerate dehydrogenase
1.2.1.4 aldehyde dehydrogenase (NADP+)
1.2.1.5 aldehyde dehydrogenase [NAD(P)+]
1.2.1.8 betaine-aldehyde dehydrogenase
1.2.1.89 D-glyceraldehyde dehydrogenase (NADP+)






D-glycerate + ATP <=> H+ + 2-phospho-D-glycerate + ADP 2.7.1.165 glycerate 2-kinase

D-glucono-1,5-lactone + H2O <=> H+ + D-gluconate 3.1.1.17 gluconolactonase
3.1.1.35 dihydrocoumarin hydrolase


Visualization of the pathway